Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM431933
Substrate
n/a
Meas. Tech.
IPOne assay
EC50
27.0±n/a nM
Citation
 Eckhardt, M; Wagner, H; Peters, S Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes US Patent  US10550127 Publication Date 2/4/2020 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM431933
Synonyms:
((S)-6-{(R)-4-[2,6-Dimethyl-4-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-7-fluoro-indan-1-ylamino}-2,3-dihydro-furo[3,2-c]pyridin-3-yl)-acetic Acid | US10550127, Example 19
Type:
Small organic molecule
Emp. Form.:
C32H30FN3O4
Mol. Mass.:
539.5967
SMILES:
Cc1cc(cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1)-c1ccc(=O)n(C)c1 |r,wU:24.27,wD:14.20,(-1.84,-.64,;-3.35,-.32,;-4.38,-1.46,;-5.89,-1.14,;-6.36,.32,;-5.33,1.46,;-5.81,2.93,;-3.83,1.14,;-2.8,2.29,;-3.27,3.75,;-2.24,4.9,;-.73,4.58,;.3,5.72,;-.26,3.11,;1.15,2.49,;.99,.96,;-.52,.64,;-1.29,1.97,;2.48,3.26,;3.82,2.49,;5.15,3.26,;6.48,2.49,;7.95,2.96,;8.85,1.72,;7.95,.47,;8.42,-.99,;9.93,-1.31,;10.96,-.17,;10.41,-2.78,;6.48,.95,;5.15,.18,;3.82,.95,;-6.92,-2.29,;-6.44,-3.75,;-7.47,-4.9,;-8.98,-4.58,;-10.01,-5.72,;-9.45,-3.11,;-10.96,-2.79,;-8.42,-1.97,)|
Structure:
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