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Target
E3 ubiquitin-protein ligase Mdm2 [23-127]
Ligand
BDBM431987
Substrate
n/a
Meas. Tech.
MDM2-p53 Inhibition AlphaScreen
IC50
16.0±n/a nM
Citation
 Weinstabl, H; Gollner, A; Ramharter, J; Wunberg, T Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors US Patent  US10576064 Publication Date 3/3/2020 
Target
Name:
E3 ubiquitin-protein ligase Mdm2 [23-127]
Synonyms:
MDM2 | MDM2-MDMX (aa 23-127) | MDM2_HUMAN
Type:
Oncoprotein
Mol. Mass.:
12198.94
Organism:
Homo sapiens (Human)
Description:
Q00987[23-127]
Residue:
105
Sequence:
EQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRC
  
Inhibitor
Name:
BDBM431987
Synonyms:
US10576064, Example I-188
Type:
Small organic molecule
Emp. Form.:
C36H29Cl2FN4O7
Mol. Mass.:
719.542
SMILES:
CCOc1cccc(CN2[C@H]3CCN(C(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]22C(=O)Nc3cc(Cl)ccc23)c2ccc(cc2[N+]([O-])=O)C(O)=O)c1 |r|
Structure:
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