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Target
E3 ubiquitin-protein ligase Mdm2 [23-127]
Ligand
BDBM431990
Substrate
n/a
Meas. Tech.
MDM2-p53 Inhibition AlphaScreen
IC50
114±n/a nM
Citation
 Weinstabl, H; Gollner, A; Ramharter, J; Wunberg, T Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors US Patent  US10576064 Publication Date 3/3/2020 
Target
Name:
E3 ubiquitin-protein ligase Mdm2 [23-127]
Synonyms:
MDM2 | MDM2-MDMX (aa 23-127) | MDM2_HUMAN
Type:
Oncoprotein
Mol. Mass.:
12198.94
Organism:
Homo sapiens (Human)
Description:
Q00987[23-127]
Residue:
105
Sequence:
EQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRC
  
Inhibitor
Name:
BDBM431990
Synonyms:
US10576064, Example I-194
Type:
Small organic molecule
Emp. Form.:
C33H30Cl2FN3O5
Mol. Mass.:
638.513
SMILES:
COc1cc(ccc1N1CC[C@H]2[C@H]([C@H](c3cccc(Cl)c3F)[C@@]3(N2CC2CC2C)C(=O)Nc2cc(Cl)ccc32)C1=O)C(O)=O |r|
Structure:
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