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Target
E3 ubiquitin-protein ligase Mdm2 [23-127]
Ligand
BDBM432008
Substrate
n/a
Meas. Tech.
MDM2-p53 Inhibition AlphaScreen
IC50
12.0±n/a nM
Citation
 Weinstabl, H; Gollner, A; Ramharter, J; Wunberg, T Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors US Patent  US10576064 Publication Date 3/3/2020 
Target
Name:
E3 ubiquitin-protein ligase Mdm2 [23-127]
Synonyms:
MDM2 | MDM2-MDMX (aa 23-127) | MDM2_HUMAN
Type:
Oncoprotein
Mol. Mass.:
12198.94
Organism:
Homo sapiens (Human)
Description:
Q00987[23-127]
Residue:
105
Sequence:
EQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRC
  
Inhibitor
Name:
BDBM432008
Synonyms:
US10576064, Example I-226
Type:
Small organic molecule
Emp. Form.:
C29H21Cl2F4N3O4
Mol. Mass.:
622.394
SMILES:
OC(=O)c1ccc(cc1)N1C[C@H]2[C@H]([C@H](c3cccc(Cl)c3F)[C@@]3(N2CCC(F)(F)F)C(=O)Nc2cc(Cl)ccc32)C1=O |r|
Structure:
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