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Target
Mu-type opioid receptor
Ligand
BDBM432290
Substrate
n/a
Meas. Tech.
Human mu-Opioid Receptor Radioligand Assay
Ki
<100±n/a nM
Citation
 Goya, P; Torrens-Jover, A; Almansa-Rosales, C; Diaz-Fernández, J; Caamaño-Moure, A Arylamide derivatives having multimodal activity against pain US Patent  US10577360 Publication Date 3/3/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM432290
Synonyms:
N-{(1s,4s)-4-[Benzyl(methyl)amino]cyclohexyl}-3-hydroxy- N-{1-[3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-1H- pyrazol-3-yl}benzamide | US10577360, Example 154
Type:
Small organic molecule
Emp. Form.:
C33H34N6O3
Mol. Mass.:
562.6615
SMILES:
CN(Cc1ccccc1)[C@H]1CC[C@H](CC1)N(C(=O)c1cccc(O)c1)c1ccn(n1)-c1cccc(c1)-c1nnc(C)o1 |r,wU:12.16,9.9,(4.05,.08,;3.65,1.57,;4.74,2.66,;6.22,2.26,;6.62,.77,;8.11,.37,;9.2,1.46,;8.8,2.95,;7.31,3.35,;2.16,1.97,;1.07,.88,;-.42,1.28,;-.82,2.76,;.27,3.85,;1.76,3.45,;-2.3,3.16,;-2.7,4.65,;-1.61,5.74,;-4.19,5.05,;-5.28,3.96,;-6.77,4.36,;-7.16,5.84,;-6.07,6.93,;-6.47,8.42,;-4.59,6.53,;-3.39,2.07,;-4.93,2.07,;-5.41,.61,;-4.16,-.3,;-2.92,.61,;-4.16,-1.84,;-2.83,-2.61,;-2.83,-4.15,;-4.16,-4.92,;-5.5,-4.15,;-5.5,-2.61,;-6.83,-4.92,;-8.29,-4.44,;-9.2,-5.69,;-8.29,-6.93,;-8.69,-8.42,;-6.83,-6.46,)|
Structure:
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