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Target
Histone-lysine N-methyltransferase SMYD3
Ligand
BDBM433076
Substrate
n/a
Meas. Tech.
SMYD3 Biochemical Assay
IC50
1.21±n/a nM
Citation
 Mitchell, LH; Bell, AS; Chesworth, R; Foley, MA; Kuntz, KW; Mills, JE; Munchhof, MJ Substituted piperidine compounds US Patent  US10577363 Publication Date 3/3/2020 
Target
Name:
Histone-lysine N-methyltransferase SMYD3
Synonyms:
SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:
Enzyme
Mol. Mass.:
49101.22
Organism:
Homo sapiens (Human)
Description:
Q9H7B4-2
Residue:
428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS
  
Inhibitor
Name:
BDBM433076
Synonyms:
5-cyclopropyl-N-((2S,4S)-1-((4-((2- hydroxyethyl)(methyl)amino)piperidin-1- yl)sulfonyl)-2-methylpiperidin-4- yl)isoxazole-3-carboxamide | US10577363, Compound 780
Type:
Small organic molecule
Emp. Form.:
C21H35N5O5S
Mol. Mass.:
469.598
SMILES:
C[C@H]1C[C@H](CCN1S(=O)(=O)N1CCC(CC1)N(C)CCO)NC(=O)c1cc(on1)C1CC1 |r|
Structure:
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