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Target
Hydroxyproline dehydrogenase [147-515]
Ligand
BDBM433362
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
<1000000±n/a nM
Citation
 Lowther, WT; Holmes, RP; Yohannes, D HYPDH inhibitors and methods of use for the treatment of kidney stones US Patent  US10562844 Publication Date 2/18/2020 
Target
Name:
Hydroxyproline dehydrogenase [147-515]
Synonyms:
HSPOX1 | HYPDH | HYPDH_HUMAN | Hydroxyproline dehydrogenase (HYPDH)(aa 147-515) | PRODH2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43085.33
Organism:
Homo sapiens (Human)
Description:
aa 147-515
Residue:
389
Sequence:
SGAFLRASVYGQFVAGETAEEVKGCVQQLRTLSLRPLLAVPTEEEPDSAAKSGEAWYEGNLGAMLRCVDLSRGLLEPPSLAEASLMQLKVTALTSTRLCKELASWVRRPGASLELSPERLAEAMDSGQNLQVSCLNAEQNQHLRASLSRLHRVAQYARAQHVRLLVDAEYTSLNPALSLLVAALAVRWNSPGEGGPWVWNTYQACLKDTFERLGRDAEAAHRAGLAFGVKLVRGAYLDKERAVAQLHGMEDPTQPDYEATSQSYSRCLELMLTHVARHGPMCHLMVASHNEESVRQATKRMWELGIPLDGTVCFGQLLGMCDHVSLALGQAGYVVYKSIPYGSLEEVIPYLIRRAQENRSVLQGARREQELLSQELWRRLLPGCRRIPH
  
Inhibitor
Name:
BDBM433362
Synonyms:
US10562844, Compound 12
Type:
Small organic molecule
Emp. Form.:
C5H8O3S
Mol. Mass.:
148.18
SMILES:
OC1CC(CS1)C(O)=O
Structure:
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