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Target
Prokineticin receptor 1
Ligand
BDBM433560
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
1740±n/a nM
Citation
 Goldby, A; Jenkins, K; Teall, M Piperidine derivatives for use in the treatment or prevention of psychiatric and neurological conditions US Patent  US10562882 Publication Date 2/18/2020 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Homo sapiens (Human)
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM433560
Synonyms:
N-Methyl-5-{3-[1-(propan-2-yl)-1H-1,3-benzodiazol-2-yl]piperidine-1-carbonyl}pyridazin-3-amine | US10562882, Example 6
Type:
Small organic molecule
Emp. Form.:
C21H26N6O
Mol. Mass.:
378.4707
SMILES:
CNc1cc(cnn1)C(=O)N1CCCC(C1)c1nc2ccccc2n1C(C)C
Structure:
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