Reaction Details Report a problem with these data
Target
Prokineticin receptor 1
Ligand
BDBM433638
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
2080±n/a nM
Citation
 Goldby, A; Jenkins, K; Teall, M Piperidine derivatives for use in the treatment or prevention of psychiatric and neurological conditions US Patent  US10562882 Publication Date 2/18/2020 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Homo sapiens (Human)
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM433638
Synonyms:
5-({3-[5-Chloro-3-(trifluoromethyl)pyridin-2-yl]-3-methoxypiperidin-1-yl}carbonyl)-N-methylpyridazin-3-amine | US10562882, Example 30
Type:
Small organic molecule
Emp. Form.:
C18H19ClF3N5O2
Mol. Mass.:
429.824
SMILES:
CNc1cc(cnn1)C(=O)N1CCCC(C1)(OC)c1ncc(Cl)cc1C(F)(F)F
Structure:
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