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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM434706
Substrate
n/a
Meas. Tech.
Kinase Activity Inhibition Assay
IC50
550±n/a nM
Citation
 Xu, J; Cai, Q; Cha, MY; Kim, M IRAK4 inhibitor and use thereof US Patent  US10562902 Publication Date 2/18/2020 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM434706
Synonyms:
US10562902, Compound 112 | US10562902, Compound 113
Type:
Small organic molecule
Emp. Form.:
C23H22N8O2
Mol. Mass.:
442.4732
SMILES:
Cn1cc(cn1)-n1ccc2nc(Nc3cnn(c3)-c3ccccc3)nc(O[C@H]3CCOC3)c12
Structure:
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