Reaction Details Report a problem with these data
Target
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Ligand
BDBM424119
Substrate
n/a
Meas. Tech.
TYK2 JH2 Domain Binding Assay
Kd
5.5±n/a nM
Citation
 Masse, CE; Greenwood, JR; Mondal, S; Cowen, SD; McLean, TH TYK2 inhibitors and uses thereof US Patent  US10577373 Publication Date 3/3/2020 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
36941.98
Organism:
Homo sapiens (Human)
Description:
P29597 (aa 556-888)
Residue:
333
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
  
Inhibitor
Name:
BDBM424119
Synonyms:
US10508120, Compound I-574 | US10577373, Compound I-574 | US11046698, Compound I-574
Type:
Small organic molecule
Emp. Form.:
C23H27N9O
Mol. Mass.:
445.5202
SMILES:
CNc1cc(nc2c(cnn12)C(=O)NC1CC1)-n1cc(N2CCN(C)CC2)c2ncccc12
Structure:
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