Target
Tyrosine-protein kinase BTK
Ligand
BDBM348616
Substrate
n/a
Meas. Tech.
In vitro BTK kinase assay
IC50
<100±n/a nM
Citation
 Bui, MConlon, PCuervo, JHErlanson, DAFan, JGuan, BHopkins, BTJenkins, TJKumaravel, GLugovskoy, AAMarcotte, DPowell, NScott, DSilvian, LTaveras, AWang, DZhong, M Bruton's tyrosine kinase inhibitors US Patent  US10577374 Publication Date 3/3/2020 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM348616
Synonyms:
US10577374, Compound 339 | US9790229, Compound 339
Type:
Small organic molecule
Emp. Form.:
C23H23Cl2F3N6O
Mol. Mass.:
527.37
SMILES:
FC(F)(F)[C@H]1CCN(C[C@@H]1N1CCCC(Nc2cc(Cl)cc(Cl)c2)C1=O)c1ncnc2[nH]ccc12 |r|
Structure:
Search PDB for entries with ligand similarity: