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Target
Eosinophil peroxidase
Ligand
BDBM434841
Substrate
n/a
Meas. Tech.
EPX Bromination Assay
IC50
190±n/a nM
Citation
 Smallheer, JM; Kick, EK; Valente, MN; Hu, CH; Halpern, OS; Jusuf, S Macrocyclic inhibitors of myeloperoxidase US Patent  US10577383 Publication Date 3/3/2020 
Target
Name:
Eosinophil peroxidase
Synonyms:
EPER | EPO | EPP | EPX | PERE_HUMAN
Type:
Protein
Mol. Mass.:
81087.94
Organism:
Human
Description:
P11678
Residue:
715
Sequence:
MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAERCSDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRNQINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVNCSRIPRLNLSAWRGT
  
Inhibitor
Name:
BDBM434841
Synonyms:
7-{18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,1 6 ]pentacosa-1(23),4,6(25),12,14,16(24),19,21-octaen-7-yl}-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | US10577383, Example 2
Type:
Small organic molecule
Emp. Form.:
C26H26N8O
Mol. Mass.:
466.5376
SMILES:
Nc1cc(C2CCNCc3cccc(COc4cccc(Cn5cc2cn5)c4)c3)c2nn[nH]c2n1
Structure:
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