Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1
Ligand
BDBM297578
Substrate
n/a
Meas. Tech.
NTR1 Ca2+ Flux Dose Response
EC50
1250±n/a nM
Citation
 Pinkerton, AB; Hershberger, PM; Peddibhotla, S; Maloney, PR; Hedrick, MP Small molecule agonists of neurotensin receptor 1 US Patent  US10584103 Publication Date 3/10/2020 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM297578
Synonyms:
2-cyclopropyl-4-[4-(2-methoxy- phenyl)-piperidin-1-yl]-6-(3- methoxy-pyrrolidin-1-yl)- quinazoline | US10118902, Example 80 | US10584103, Example 80
Type:
Small organic molecule
Emp. Form.:
C28H34N4O2
Mol. Mass.:
458.5952
SMILES:
COC1CCN(C1)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1CC1
Structure:
Search PDB for entries with ligand similarity: