Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM434975
Substrate
n/a
Meas. Tech.
IC50 for Inhibition of the Test Compounds on URAT1
IC50
1020±n/a nM
Citation
 Zhao, G; Liu, W; Shang, Q; Zhou, Z; Wang, Y; Li, Y; Zhang, H; Li, C; Liu, C; Liu, Y; Xie, Y; Wu, J; Chen, H; Xu, W; Tang, L Carboxylic acid URAT1 inhibitor containing diarylmethane structure, preparation method and use thereof US Patent  US10584104 Publication Date 3/10/2020 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM434975
Synonyms:
US10584104, Compound of Example 17
Type:
Small organic molecule
Emp. Form.:
C20H20BrN3O2S
Mol. Mass.:
446.361
SMILES:
CC(C)(Sc1nnc(Br)n1Cc1ccc(C2CC2)c2ccccc12)C(O)=O
Structure:
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