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Target
Proto-oncogene tyrosine-protein kinase receptor Ret
Ligand
BDBM435004
Substrate
n/a
Meas. Tech.
RET Wild Type Assay at KM
IC50
<500±n/a nM
Citation
 Brubaker, JD; Kim, JL; Wilson, KJ; Wilson, D; DiPietro, LV Inhibitors of RET US Patent  US10584114 Publication Date 3/10/2020 
Target
Name:
Proto-oncogene tyrosine-protein kinase receptor Ret
Synonyms:
CDHF12 | CDHR16 | Cadherin family member 12 | PTC | Proto-oncogene c-Ret | RET | RET51 | RET_HUMAN | Tyrosine-protein kinase Ret (RET)
Type:
Protein
Mol. Mass.:
124318.29
Organism:
Homo sapiens (Human)
Description:
P07949
Residue:
1114
Sequence:
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS
  
Inhibitor
Name:
BDBM435004
Synonyms:
US10584114, Compound 120 | US11279688, Compound 120
Type:
Small organic molecule
Emp. Form.:
C27H31FN8O2
Mol. Mass.:
518.5858
SMILES:
C[C@H](NC(=O)[C@H]1CC[C@@](O)(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,wU:1.0,wD:5.4,8.8,(4,4.24,;4,2.7,;2.66,1.93,;1.33,2.7,;1.33,4.24,;-.01,1.93,;-1.34,2.69,;-2.67,1.93,;-2.67,.38,;-2.67,-1.16,;-1.34,-.38,;-.01,.38,;-4.01,-.39,;-4.01,-1.93,;-5.34,-2.7,;-5.34,-4.24,;-6.67,-1.93,;-6.67,-.39,;-8.01,.38,;-9.34,-.39,;-10.75,.24,;-11.78,-.9,;-13.31,-.74,;-11.01,-2.24,;-9.5,-1.92,;-5.34,.38,;5.33,1.93,;5.33,.39,;6.66,-.38,;8,.39,;8,1.93,;6.66,2.7,;9.33,-.38,;10.64,.43,;11.82,-.56,;13.31,-.18,;11.24,-1.99,;9.7,-1.88,)|
Structure:
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