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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM435101
Substrate
n/a
Meas. Tech.
QC Inhibition Assay
Ki
2053±n/a nM
Citation
 Chen, C; Shih, C; Chen, C; Wang, H; Huang, K Benzimidazole compounds and use thereof for treating Alzheimer's Disease or Huntington's Disease US Patent  US10584120 Publication Date 3/10/2020 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM435101
Synonyms:
US10584120, Compound 35
Type:
Small organic molecule
Emp. Form.:
C21H15F3N4OS
Mol. Mass.:
428.43
SMILES:
FC(F)(F)c1cc(cs1)-c1ccc(cc1)[C@@H]1CNC(=O)N1c1ccc2[nH]cnc2c1 |r|
Structure:
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