Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM435117
Substrate
n/a
Meas. Tech.
QC Inhibition Assay
Ki
13.0±n/a nM
Citation
 Chen, C; Shih, C; Chen, C; Wang, H; Huang, K Benzimidazole compounds and use thereof for treating Alzheimer's Disease or Huntington's Disease US Patent  US10584120 Publication Date 3/10/2020 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM435117
Synonyms:
US10584120, Compound 50
Type:
Small organic molecule
Emp. Form.:
C24H17ClN8O2
Mol. Mass.:
484.897
SMILES:
Clc1ccc(Cn2nnc(n2)-c2ccc(cc2)C2N(C(=O)NC2=O)c2ccc3[nH]cnc3c2)cc1
Structure:
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