Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM435126
Substrate
n/a
Meas. Tech.
QC Inhibition Assay
Ki
7.00±n/a nM
Citation
 Chen, C; Shih, C; Chen, C; Wang, H; Huang, K Benzimidazole compounds and use thereof for treating Alzheimer's Disease or Huntington's Disease US Patent  US10584120 Publication Date 3/10/2020 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM435126
Synonyms:
US10584120, Compound 60
Type:
Small organic molecule
Emp. Form.:
C21H16F2N4OS
Mol. Mass.:
410.44
SMILES:
Cc1cc(cs1)-c1ccc(C2CNC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
Structure:
Search PDB for entries with ligand similarity: