Target
Serine hydroxymethyltransferase, mitochondrial
Ligand
BDBM285663
Substrate
n/a
Meas. Tech.
Inhibition of Human SHMT
IC50
1.40±n/a nM
Citation
 Rabinowitz, JDKim, HDucker, GSGhergurovich, JM SHMT inhibitors US Patent  US10584132 Publication Date 3/10/2020 
Target
Name:
Serine hydroxymethyltransferase, mitochondrial
Synonyms:
GLYM_HUMAN | Glycine hydroxymethyltransferase | SHMT | SHMT2 | Serine methylase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56004.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
504
Sequence:
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDEH
  
Inhibitor
Name:
BDBM285663
Synonyms:
US10077273, Compound 11 | US10584132, Compound 11 | US10934305, Compound 11
Type:
Small organic molecule
Emp. Form.:
C23H22F3N5O2
Mol. Mass.:
457.4483
SMILES:
CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)C#CCCC(N)=O |c:13|
Structure:
Search PDB for entries with ligand similarity: