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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM435242
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
15.5±n/a nM
Citation
 Imbriglio, J; Liang, R; London, C; Marby, K; Tata, J; You, M; Xiong, Y Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US10568876 Publication Date 2/25/2020 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM435242
Synonyms:
US10568876, Example 21 | US10568876, Example 7 | methyl 3-(2-(tert-butylcarbamoyl)-8- ((2-(3-methyl-1,2,4-oxadiazol-5- yl)cyclopropanecarboxamido)methyl)- 1,2,3,4-tetrahydroisoquinolin-5- yl)benzoate (mixture of 4 isomers)
Type:
Small organic molecule
Emp. Form.:
C30H35N5O5
Mol. Mass.:
545.6294
SMILES:
COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2nc(C)no2)c2CN(CCc12)C(=O)NC(C)(C)C
Structure:
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