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Target
Tyrosine-protein kinase BTK
Ligand
BDBM435482
Substrate
n/a
Meas. Tech.
Lanthscreen Eu Kinase Binding assay
IC50
580±n/a nM
Citation
 Bosanac, T; Bentzien, J; Burke, MJ; DiSalvo, DT; Mao, W; Soleymanzadeh, F; Westbrook, JA; Xiong, Z Isoquinolones as BTK inhibitors US Patent  US10570118 Publication Date 2/25/2020 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM435482
Synonyms:
US10570118, Example 36
Type:
Small organic molecule
Emp. Form.:
C31H29N3O4
Mol. Mass.:
507.5797
SMILES:
CN(Cc1cc2cc(ccc2c(=O)n1-c1cccc(c1CO)-c1cccc(c1)C(N)=O)C1CC1)C(=O)C=C |(5.9,-1.82,;4.56,-2.59,;3.23,-1.82,;3.23,-.28,;4.56,.49,;4.56,2.03,;5.9,2.8,;5.9,4.34,;4.56,5.11,;3.23,4.34,;3.23,2.8,;1.9,2.03,;.56,2.8,;1.9,.49,;.56,-.28,;.56,-1.82,;-.77,-2.59,;-2.1,-1.82,;-2.1,-.28,;-.77,.49,;-.77,2.03,;-2.1,2.8,;-3.44,.49,;-3.44,2.03,;-4.77,2.8,;-6.1,2.03,;-6.1,.49,;-4.77,-.28,;-7.44,-.28,;-8.77,.49,;-7.44,-1.82,;7.23,5.11,;8.77,5.11,;8,6.44,;4.56,-4.13,;5.9,-4.9,;3.23,-4.9,;3.23,-6.44,)|
Structure:
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