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Target
Cyclin-dependent kinase 6
Ligand
BDBM435714
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
18.7±n/a nM
Citation
 Wang, S; Chen, K; Liu, X; Hu, Y; Liu, B; Peng, Y; Luo, H; Han, Y; Wang, S; Liu, M; Xu, H Substituted pyrrolopyrimidine CDK inhibitor, pharmaceutical composition containing same and use thereof US Patent  US10570141 Publication Date 2/25/2020 
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM435714
Synonyms:
US10570141, Example 3
Type:
Small organic molecule
Emp. Form.:
C24H33N7O2S
Mol. Mass.:
483.63
SMILES:
CN(C)C1CCN(CC1)c1ccc(Nc2ncc3cc(n(C4CCCC4)c3n2)S(C)(=O)=O)nc1
Structure:
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