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Target
Cyclin-dependent kinase 4
Ligand
BDBM435715
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2.57±n/a nM
Citation
 Wang, S; Chen, K; Liu, X; Hu, Y; Liu, B; Peng, Y; Luo, H; Han, Y; Wang, S; Liu, M; Xu, H Substituted pyrrolopyrimidine CDK inhibitor, pharmaceutical composition containing same and use thereof US Patent  US10570141 Publication Date 2/25/2020 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM435715
Synonyms:
US10570141, Example 4
Type:
Small organic molecule
Emp. Form.:
C22H26N6O2S
Mol. Mass.:
438.546
SMILES:
CS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)C3=CCNCC3)nc2n1C1CCCC1 |t:18|
Structure:
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