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Target
Cyclin-dependent kinase 6
Ligand
BDBM435717
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
30.6±n/a nM
Citation
 Wang, S; Chen, K; Liu, X; Hu, Y; Liu, B; Peng, Y; Luo, H; Han, Y; Wang, S; Liu, M; Xu, H Substituted pyrrolopyrimidine CDK inhibitor, pharmaceutical composition containing same and use thereof US Patent  US10570141 Publication Date 2/25/2020 
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM435717
Synonyms:
US10570141, Example 6
Type:
Small organic molecule
Emp. Form.:
C24H29N7O
Mol. Mass.:
431.5334
SMILES:
CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)C3=CCNCC3)nc2n1C1CCCC1 |t:19|
Structure:
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