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Target
5'-nucleotidase
Ligand
BDBM435829
Substrate
n/a
Meas. Tech.
Inhibition Enzyme In Vitro Assay
IC50
51.0±n/a nM
Citation
 Billedeau, RJ; Li, J; Chen, L Ectonucleotidase inhibitors and methods of use thereof US Patent  US10570167 Publication Date 2/25/2020 
Target
Name:
5'-nucleotidase
Synonyms:
5'-NT | 5'-nucleotidase (CD73) | 5NTD_HUMAN | CD_antigen=CD73 | Ecto-5'-nucleotidase | Ecto-5-nucleotidase (e5'NT) | NT5 | NT5E | NTE
Type:
Enzyme
Mol. Mass.:
63371.54
Organism:
Homo sapiens (Human)
Description:
P21589
Residue:
574
Sequence:
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
  
Inhibitor
Name:
BDBM435829
Synonyms:
US10570167, Cpd. # 149 | US11034715, Cpd. # 149
Type:
Small organic molecule
Emp. Form.:
C21H22ClN5O8
Mol. Mass.:
507.881
SMILES:
C[C@@]1(O)[C@@H](COC(Cc2ccccc2)(C(O)=O)C(O)=O)O[C@H]([C@@H]1O)n1cnc2c(N)nc(Cl)nc12 |r|
Structure:
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