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Target
UL37 immediate early glycoprotein
Ligand
BDBM435726
Substrate
n/a
Meas. Tech.
The inhibition of HCMV replication by digitoxin
EC50
113±2.86 nM
Citation
 Boger, R Cardiac glycoside analogs and their use in methods for inhibition of viral infection US Patent  US10610539 Publication Date 4/7/2020 
Target
Name:
UL37 immediate early glycoprotein
Synonyms:
UL37 | VGLI_HCMVA
Type:
Protein
Mol. Mass.:
56144.76
Organism:
HHV-5
Description:
P16778
Residue:
487
Sequence:
MSPVYVNLLGSVGLLAFWYFSYRWIQRKRLEDPLPPWLRKKKACALTRRSRHRLRRQHGVIDGENSETERSVDLVAALLAEAGEESVTEDTEREDTEEEREDEEEENEARTPEVNPIDAEGLSGLAREACEALKKALRRHRFLWQRRQRARMLQHNGPQQSHHAAVFCRVHGLRGFQVSVWLLLTLLWSTGHGVSVRCTYHGTDVNRTSNTTSMNCHLNCTRNHTQIYNGPCLGTEARLPLNVTFNQSRRKWHSVMLKFGFQYHLEGWFPLRVLNESREINVTEVHGEVACFRNDTNVTVGQLTLNFTGHSYVLRAIAHTSPFESYVRWEETNVTDNATSSENTTTVMSTLTKYAESDYIFLQDMCPRFLKRTVKLTRNKTKHNVTVTGNNMTTLPVWTPECKGWTYWTTLSVMWRNRRSALLRAKSRALGHWALLSICTVAAGSIALLSLFCILLIGLRRDLLEDFRYICRDEGSSSTKNDVHRIV
  
Inhibitor
Name:
BDBM435726
Synonyms:
US10610539, Compound Tris-L-amicetose
Type:
Small organic molecule
Emp. Form.:
C61H98O21
Mol. Mass.:
1167.4182
SMILES:
CC1OC(O[C@H]2C[C@H](O)C(O[C@@H]3C[C@H](O)C(OC4CC(OC5C(C)OC(OC6C(O)CC(O[C@H]7CC[C@@]8(C)[C@H](CC[C@@H]9[C@@H]8CC[C@]8(C)[C@H](CC[C@]98O)C8=CC(=O)OC8)C7)OC6C)C(C)C5O)OC(C)C4C)OC3C)OC2C)[C@@H](O)C[C@@H]1O |r,t:55|
Structure:
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