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Target
Prolyl endopeptidase-like
Ligand
BDBM298359
Substrate
n/a
Meas. Tech.
POP Inhibition Assays
IC50
176±8.3 nM
Citation
 Giralt Lledó, E; Tarragó Clua, T; Prades Cosano, R; Royo Gracia, S 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives US Patent  US10611727 Publication Date 4/7/2020 
Target
Name:
Prolyl endopeptidase-like
Synonyms:
KIAA0436 | PPCEL_HUMAN | PREPL | Prolylendopeptidase-like
Type:
Protein
Mol. Mass.:
83923.47
Organism:
Human
Description:
Q4J6C6
Residue:
727
Sequence:
MQQKTKLFLQALKYSIPHLGKCMQKQHLNHYNFADHCYNRIKLKKYHLTKCLQNKPKISELARNIPSRSFSCKDLQPVKQENEKPLPENMDAFEKVRTKLETQPQEEYEIINVEVKHGGFVYYQEGCCLVRSKDEEADNDNYEVLFNLEELKLDQPFIDCIRVAPDEKYVAAKIRTEDSEASTCVIIKLSDQPVMEASFPNVSSFEWVKDEEDEDVLFYTFQRNLRCHDVYRATFGDNKRNERFYTEKDPSYFVFLYLTKDSRFLTINIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTNVGEPTEFKLMRTAADTPAIMNWDLFFTMKRNTKVIDLDMFKDHCVLFLKHSNLLYVNVIGLADDSVRSLKLPPWACGFIMDTNSDPKNCPFQLCSPIRPPKYYTYKFAEGKLFEETGHEDPITKTSRVLRLEAKSKDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKITAQIKFLYEELGLDSTSVFEDLKKYLKF
  
Inhibitor
Name:
BDBM298359
Synonyms:
(S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-(trifluoromethyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile | US10125097, Example 8 | US10611727, Example 8
Type:
Small organic molecule
Emp. Form.:
C27H28F3N3O5
Mol. Mass.:
531.5235
SMILES:
COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@H](C[C@H]1C(=O)N1CCC[C@H]1C#N)C(F)(F)F |r|
Structure:
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