Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM349551
Substrate
n/a
Meas. Tech.
Competitive Radioligand Binding Assay
Ki
2.60±n/a nM
Citation
 Rishton, GM; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent  US10611728 Publication Date 4/7/2020 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM349551
Synonyms:
US10207991, Ex. Cpd. No. 66 | US10611728, Example Compound 66 | US11691947, Example 66
Type:
Small organic molecule
Emp. Form.:
C24H33NO4S
Mol. Mass.:
431.588
SMILES:
CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3cccc(c3C2)S(C)(=O)=O)ccc1O
Structure:
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