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Target
Voltage-dependent calcium channel gamma-8 subunit
Ligand
BDBM435921
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
IC50
20.0±n/a nM
Citation
 Ameriks, MK; Ravula, S; Swanson, DM; Savall, BM Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators US Patent  US10611730 Publication Date 4/7/2020 
Target
Name:
Voltage-dependent calcium channel gamma-8 subunit
Synonyms:
CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43326.96
Organism:
Homo sapiens (Human)
Description:
Q8WXS5
Residue:
425
Sequence:
MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV
  
Inhibitor
Name:
BDBM435921
Synonyms:
(+-)-5-[2-Chloro-6-[(2,2-difluorocyclopropyl)methoxy]phenyl]-1,3-dihydrobenzimidazol-2-one; | US10611730, Example 93
Type:
Small organic molecule
Emp. Form.:
C17H13ClF2N2O2
Mol. Mass.:
350.747
SMILES:
FC1(F)CC1COc1cccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1
Structure:
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