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Target
Voltage-dependent calcium channel gamma-8 subunit
Ligand
BDBM435959
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
IC50
31.6±n/a nM
Citation
 Ameriks, MK; Ravula, S; Swanson, DM; Savall, BM Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators US Patent  US10611730 Publication Date 4/7/2020 
Target
Name:
Voltage-dependent calcium channel gamma-8 subunit
Synonyms:
CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43326.96
Organism:
Homo sapiens (Human)
Description:
Q8WXS5
Residue:
425
Sequence:
MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV
  
Inhibitor
Name:
BDBM435959
Synonyms:
2-[3-Bromo-2-(2-oxo-1,3-dihydrobenzimidazol-5-yl)phenyl]acetonitrile; | US10611730, Example 132
Type:
Small organic molecule
Emp. Form.:
C15H10BrN3O
Mol. Mass.:
328.163
SMILES:
Brc1cccc(CC#N)c1-c1ccc2[nH]c(=O)[nH]c2c1
Structure:
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