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Target
Neurotensin receptor type 1
Ligand
BDBM297504
Substrate
n/a
Meas. Tech.
NTR1 Ca2+ Flux Dose Response
EC50
1250±n/a nM
Citation
 Pinkerton, AB; Hershberger, PM; Peddibhotla, S; Maloney, PR; Hedrick, MP Small molecule agonists of neurotensin receptor 1 US Patent  US10118902 Publication Date 11/6/2018 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM297504
Synonyms:
2-({4-[4-(2-azetidin-1-yl-phenyl)- piperidin-1-yl]-2-cyclopropyl- quinazolin-6-yl}-methyl-amino)- ethanol | US10118902, Example 6 | US10584103, Example 6
Type:
Small organic molecule
Emp. Form.:
C28H35N5O
Mol. Mass.:
457.6104
SMILES:
CN(CCO)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3N3CCC3)c2c1)C1CC1
Structure:
Search PDB for entries with ligand similarity: