Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1
Ligand
BDBM297549
Substrate
n/a
Meas. Tech.
NTR1 Ca2+ Flux Dose Response
EC50
6000±n/a nM
Citation
Pinkerton, AB; Hershberger, PM; Peddibhotla, S; Maloney, PR; Hedrick, MP Small molecule agonists of neurotensin receptor 1 US Patent US10118902 Publication Date 11/6/2018
More Info.:
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
Inhibitor
Name:
BDBM297549
Synonyms:
2-{[4-[4-(2-methoxy-phenyl)- piperidin-1-yl]-2-(1-methyl- cyclopentyl)-quinazolin-6-yl]- methyl-amino}-ethanol | US10118902, Example 51 | US10584103, Example 51
Type:
Small organic molecule
Emp. Form.:
C29H38N4O2
Mol. Mass.:
474.6376
SMILES:
COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(C)CCCC1