Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1
Ligand
BDBM297630
Substrate
n/a
Meas. Tech.
NTR1 Ca2+ Flux Dose Response
EC50
1250±n/a nM
Citation
Pinkerton, AB; Hershberger, PM; Peddibhotla, S; Maloney, PR; Hedrick, MP Small molecule agonists of neurotensin receptor 1 US Patent US10118902 Publication Date 11/6/2018
More Info.:
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
Inhibitor
Name:
BDBM297630
Synonyms:
2-((2-cyclopropyl-5-fluoro-4-(4- (2-methoxyphenyl)piperidin-1- yl)quinazolin-6- yl)(methyl)amino)ethanol | US10118902, Example 132 | US10118902, Example 167 | US10584103, Example 167
Type:
Small organic molecule
Emp. Form.:
C26H31FN4O2
Mol. Mass.:
450.5483
SMILES:
COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(N(C)CCO)c(F)c12)C1CC1