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Target
Neurotensin receptor type 1
Ligand
BDBM297687
Substrate
n/a
Meas. Tech.
NTR1 Ca2+ Flux Dose Response
EC50
>10000±n/a nM
Citation
 Pinkerton, AB; Hershberger, PM; Peddibhotla, S; Maloney, PR; Hedrick, MP Small molecule agonists of neurotensin receptor 1 US Patent  US10118902 Publication Date 11/6/2018 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM297687
Synonyms:
2-({2-(1-Fluoro-cyclopropyl)-4- [4-(2-methoxy-cyclohexyl)- piperidin-1-yl]-quinazolin-6- yl}-methyl-amino)-ethanol | US10118902, Example 189 | US10584103, Example 189
Type:
Small organic molecule
Emp. Form.:
C26H37FN4O2
Mol. Mass.:
456.596
SMILES:
COC1CCCCC1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CC1
Structure:
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