Reaction Details Report a problem with these data
Target
Programmed cell death protein 1
Ligand
BDBM436151
Substrate
n/a
Meas. Tech.
Homogenous Time-Resolved Fluorescence (HTRF) Binding Assay
IC50
5000±n/a nM
Citation
 Yeung, K; Grant-Young, KA; Zhu, J; Saulnier, MG; Frennesson, DB; Meng, Z; Scola, PM 1,3-dihydroxy-phenyl derivatives useful as immunomodulators US Patent  US10590105 Publication Date 3/17/2020 
Target
Name:
Programmed cell death protein 1
Synonyms:
CD_antigen=CD279 | PD1 | PDCD1 | PDCD1_HUMAN | Programmed cell death protein 1 | Protein PD-1 | hPD-1
Type:
PROTEIN
Mol. Mass.:
31650.07
Organism:
Homo sapiens
Description:
ChEMBL_108437
Residue:
288
Sequence:
MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
  
Inhibitor
Name:
BDBM436151
Synonyms:
US10590105, Example 1037
Type:
Small organic molecule
Emp. Form.:
C38H42ClN5O7
Mol. Mass.:
716.222
SMILES:
Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN[C@@](C)(CO)C(O)=O)cc2Cl)cccc1-c1cccn(CCCN2CC[C@@H](O)C2)c1=O |r|
Structure:
Search PDB for entries with ligand similarity: