Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3 [399-806]
Ligand
BDBM436193
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>1000±n/a nM
Citation
 Kong, NX; Zhou, C; Zheng, Z Heterocyclic compounds used as FGFR inhibitors US Patent  US10590109 Publication Date 3/17/2020 
Target
Name:
Fibroblast growth factor receptor 3 [399-806]
Synonyms:
FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806) | JTK4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45160.69
Organism:
Homo sapiens (Human)
Description:
aa 399-806
Residue:
408
Sequence:
RSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM436193
Synonyms:
US10590109, Compound 11
Type:
Small organic molecule
Emp. Form.:
C19H17ClN6O4
Mol. Mass.:
428.829
SMILES:
CN(C(=O)Nc1cc(Cl)c(cn1)C#N)c1ccc(CN2CCOCC2=O)c(C=O)n1
Structure:
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