Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 2 [400-821]
Ligand
BDBM436204
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>1000±n/a nM
Citation
 Kong, NX; Zhou, C; Zheng, Z Heterocyclic compounds used as FGFR inhibitors US Patent  US10590109 Publication Date 3/17/2020 
Target
Name:
Fibroblast growth factor receptor 2 [400-821]
Synonyms:
BEK | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821) | KGFR | KSAM
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47837.78
Organism:
Homo sapiens (Human)
Description:
aa 400-821
Residue:
422
Sequence:
MKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
  
Inhibitor
Name:
BDBM436204
Synonyms:
US10590109, Compound 23
Type:
Small organic molecule
Emp. Form.:
C22H26N6O4
Mol. Mass.:
438.4796
SMILES:
COCCOc1cc(NC(=O)N(C)c2ccc(C3CCNCC3)c(C=O)n2)ncc1C#N
Structure:
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