Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3 [399-806]
Ligand
BDBM436206
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>1000±n/a nM
Citation
 Kong, NX; Zhou, C; Zheng, Z Heterocyclic compounds used as FGFR inhibitors US Patent  US10590109 Publication Date 3/17/2020 
Target
Name:
Fibroblast growth factor receptor 3 [399-806]
Synonyms:
FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806) | JTK4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45160.69
Organism:
Homo sapiens (Human)
Description:
aa 399-806
Residue:
408
Sequence:
RSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM436206
Synonyms:
US10590109, Compound 24
Type:
Small organic molecule
Emp. Form.:
C24H29N7O5
Mol. Mass.:
495.531
SMILES:
COC[C@H](C)Oc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N |r|
Structure:
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