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Target
Estrogen receptor [307-554]
Ligand
BDBM300986
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
2000±n/a nM
Citation
 Barlaam, BC; O Donovan, DH; Hughes, SJ; Moss, TA; Nissink, JW; Scott, JS; Yang, B Chemical compounds US Patent  US10590130 Publication Date 3/17/2020 
Target
Name:
Estrogen receptor [307-554]
Synonyms:
ESR | ESR1 | ESR1_HUMAN | Estrogen receptor(ER) (aa 307-554) | NR3A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28281.50
Organism:
Homo sapiens (Human)
Description:
aa 307-554
Residue:
248
Sequence:
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTS
  
Inhibitor
Name:
BDBM300986
Synonyms:
N-(4-((6S,8R)- 7-((1- fluorocyclo- propyl)methyl)-8- methyl- 6,7,8,9- tetrahydro-3H- pyrazolo[4,3- f]isoquinolin- 6-yl)-3- methoxyphenyl)- 1-(3- fluoropropyl)- N- methylazetidin- 3-amine | US10131663, Example 52 | US10590130, Example 52 | US10961241, Example 52
Type:
Small organic molecule
Emp. Form.:
C29H37F2N5O
Mol. Mass.:
509.6338
SMILES:
COc1cc(ccc1[C@H]1N(CC2(F)CC2)[C@H](C)Cc2c1ccc1[nH]ncc21)N(C)C1CN(CCCF)C1 |r|
Structure:
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