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Target
Voltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103]
Ligand
BDBM436480
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
300±n/a nM
Citation
 Cuevas-Cordobés, F; Almansa-Rosales, C Tetrahydropyrimidodiazepine and dihydropyridodiazepine compounds for treating pain and pain related conditions US Patent  US10590140 Publication Date 3/17/2020 
Target
Name:
Voltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103]
Synonyms:
CA2D1_HUMAN | CACNA2D1 | CACNL2A | CCHL2A | MHS3 | Voltage-dependent calcium channel subunit alpha-2/delta-1 (aa 25-1103)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
122113.98
Organism:
Homo sapiens (Human)
Description:
aa 25-1103
Residue:
1079
Sequence:
EPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWYIIGIQFLLLWLVSGSTHRLL
  
Inhibitor
Name:
BDBM436480
Synonyms:
6-(3-(5- ((benzyl(methyl)amino) methyl)-1,3,4- oxadiazol-2-yl)phenyl)- 2-(ethylamino)-9- methyl-6,7,8,9- tetrahydro-5H- pyrimido[4,5- e][1,4]diazepin-5-one | US10590140, Example 255
Type:
Small organic molecule
Emp. Form.:
C27H30N8O2
Mol. Mass.:
498.5795
SMILES:
CCNc1ncc2c(n1)N(C)CCN(c1cccc(c1)-c1nnc(CN(C)Cc3ccccc3)o1)C2=O
Structure:
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