Reaction Details Report a problem with these data
Target
Metabotropic glutamate receptor 2
Ligand
BDBM393827
Substrate
n/a
Meas. Tech.
In Vitro GIRK Thallium Flux (60 minute) Assay
EC50
120±n/a nM
Citation
 Cosford, ND; Raveendra-Panickar, D; Sheffler, DJ; Hutchinson, JH; Gadient, RA Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof US Patent  US10597367 Publication Date 3/24/2020 
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
GRM2_RAT | Gprc1b | Grm2 | Mglur2
Type:
PROTEIN
Mol. Mass.:
95786.41
Organism:
Rattus norvegicus
Description:
ChEMBL_105034
Residue:
872
Sequence:
MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Inhibitor
Name:
BDBM393827
Synonyms:
US10597367, Example 115 | US9969726, Example 115
Type:
Small organic molecule
Emp. Form.:
C22H13F3N2O3
Mol. Mass.:
410.3454
SMILES:
OC(=O)c1cccc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccoc1
Structure:
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