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Target
Histamine H3 receptor
Ligand
BDBM438127
Substrate
n/a
Meas. Tech.
[35S]-GTPgamma-delta binding assay (antagonist)
IC50
242±n/a nM
Citation
 Xiang, J; Xu, X; Feng, Y; Eng, W Compounds as neuronal histamine receptor-3 antagonists and uses thereof US Patent  US10618886 Publication Date 4/14/2020 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM438127
Synonyms:
US10618886, Compound XXII | US10730853, Compound XXII | US11420955, Compound XXII
Type:
Small organic molecule
Emp. Form.:
C27H30F5N3O5S
Mol. Mass.:
603.601
SMILES:
COc1cc(OC2CCN(CC2)C(=O)C2CCOCC2)ccc1-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F |(.78,-31.19,;-.55,-30.42,;-.55,-28.88,;.78,-28.11,;.78,-26.57,;2.12,-25.8,;3.45,-26.57,;3.45,-28.11,;4.78,-28.88,;6.12,-28.11,;6.12,-26.57,;4.78,-25.8,;7.45,-28.88,;7.45,-30.42,;8.78,-28.11,;10.12,-28.88,;11.45,-28.11,;11.45,-26.57,;10.12,-25.8,;8.78,-26.57,;-.55,-25.8,;-1.89,-26.57,;-1.89,-28.11,;-3.22,-28.88,;-3.22,-30.42,;-1.89,-31.19,;-4.55,-31.19,;-5.89,-30.42,;-7.22,-31.19,;-8.55,-30.42,;-8.55,-28.88,;-7.22,-28.11,;-5.89,-28.88,;-4.55,-28.11,;-4.55,-26.57,;-9.89,-28.11,;-11.22,-28.88,;-9.89,-26.57,;-9.89,-29.65,;-8.55,-27.34,;-11.22,-27.34,)|
Structure:
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