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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM438459
Substrate
n/a
Meas. Tech.
IRAK4 Inhibition Assay
IC50
2.00±n/a nM
Citation
 Duncia, JV; Gardner, DS; Hynes, J; Macor, JE; Murugesan, N; Santella, JB; Wu, H; Kantheti, D; Nair, SK; Paidi, VR; Kumar, SR; Sarkunam, K; Sistla, RK; Polimera, SR Heteroaryl substituted aminopyridine compounds US Patent  US10618903 Publication Date 4/14/2020 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM438459
Synonyms:
US10618903, Example 127 | US10618903, Example 87
Type:
Small organic molecule
Emp. Form.:
C21H24FN7O2
Mol. Mass.:
425.4594
SMILES:
CC(C)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-c1cnn2cc(cnc12)C#N |r|
Structure:
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