Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM438732
Substrate
n/a
Meas. Tech.
BRD4 AlphaScreen Assay
IC50
<25±n/a nM
Citation
 Combs, AP; Sparks, RB Tricyclic heterocycles as BET protein inhibitors US Patent  US10618910 Publication Date 4/14/2020 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Homo sapiens (Human)
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM438732
Synonyms:
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)- 4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazin-2-yl]piperidin-4-yl}- 2,2-dimethylpropanamide | US10618910, Example 11
Type:
Small organic molecule
Emp. Form.:
C29H34N6O3
Mol. Mass.:
514.6187
SMILES:
Cc1noc(C)c1-c1ccc2nc(N3CCC(CC3)NC(=O)C(C)(C)C)n3[C@H](COc1c23)c1ccccn1 |r,wD:27.36,(5.3,-5.59,;3.83,-6.07,;3.36,-7.53,;1.82,-7.53,;1.34,-6.07,;-.12,-5.59,;2.59,-5.17,;2.59,-3.63,;3.92,-2.86,;3.92,-1.32,;2.59,-.55,;2.27,.96,;.62,1.12,;-.01,2.47,;.81,3.77,;.09,5.14,;-1.45,5.14,;-2.27,3.77,;-1.55,2.47,;-2.21,6.48,;-3.75,6.49,;-4.53,5.16,;-4.51,7.83,;-6.05,7.84,;-3.73,9.16,;-2.97,7.82,;-.08,-.55,;-1.41,-1.32,;-1.41,-2.86,;-.08,-3.63,;1.25,-2.86,;1.25,-1.32,;-2.75,-.55,;-2.75,.99,;-4.08,1.76,;-5.42,.99,;-5.42,-.55,;-4.08,-1.32,)|
Structure:
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