Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM438928
Substrate
n/a
Meas. Tech.
Competitive Displacement Assay
Ki
<1±n/a nM
Citation
 Wynn, TA; Alvarez, JC; Moustakas, DT; Haeberlein, M; Pennington, LD Compounds for the treatment of pain US Patent  US10604489 Publication Date 3/31/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM438928
Synonyms:
US10604489, Compound 89
Type:
Small organic molecule
Emp. Form.:
C25H31N3O2
Mol. Mass.:
405.5325
SMILES:
COC1(C2CCCC1CN(C2)C1C[C@@H](C1)c1ccccc1)c1ccnc(c1)C(N)=O |r,wD:13.17,TLB:11:9:2:5.4.6,21:2:5.4.6:8.10.9,THB:1:2:5.4.6:8.10.9,(3.48,-2.12,;2.15,-1.35,;2.15,.19,;1.35,1.5,;1.35,3.03,;-.13,3.42,;.66,2.11,;.67,.58,;-.82,.19,;-1.59,1.52,;-.11,1.13,;-2.93,.75,;-3.33,-.74,;-4.81,-.34,;-4.42,1.15,;-6.15,-1.11,;-7.48,-.34,;-8.81,-1.11,;-8.81,-2.65,;-7.48,-3.42,;-6.15,-2.65,;3.48,.96,;3.48,2.5,;4.81,3.27,;6.15,2.5,;6.15,.96,;4.81,.19,;7.48,.19,;8.81,.96,;7.48,-1.35,)|
Structure:
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