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Target
Mu-type opioid receptor
Ligand
BDBM438957
Substrate
n/a
Meas. Tech.
Competitive Displacement Assay
Ki
3±n/a nM
Citation
 Wynn, TA; Alvarez, JC; Moustakas, DT; Haeberlein, M; Pennington, LD Compounds for the treatment of pain US Patent  US10604489 Publication Date 3/31/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM438957
Synonyms:
4-((1R,5S,9R)-9-methoxy-3-((R)-pentan-2-yl)-3-azabicyclo[3.3.1]nonan-9-yl)picolinamide and 4-((1R,5S,9s)-9-methoxy-3-((S)-pentan-2-yl)-3-azabicyclo[3.3.1]nonan-9-yl)picolinamide | US10604489, Compound 118 | US11180455, Compound 118
Type:
Small organic molecule
Emp. Form.:
C20H31N3O2
Mol. Mass.:
345.479
SMILES:
CCCC(C)N1CC2CCCC(C1)C2(OC)c1ccnc(c1)C(N)=O |TLB:16:13:9.8.10:12.6.5,THB:3:5:13:9.8.10,14:13:9.8.10:12.6.5|
Structure:
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