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Target
Mu-type opioid receptor
Ligand
BDBM438958
Substrate
n/a
Meas. Tech.
Competitive Displacement Assay
Ki
<1±n/a nM
Citation
 Wynn, TA; Alvarez, JC; Moustakas, DT; Haeberlein, M; Pennington, LD Compounds for the treatment of pain US Patent  US10604489 Publication Date 3/31/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM438958
Synonyms:
4-((1R,5S,9r)-3-((1H-indol-2-yl)methyl)-9-methoxy-3-azabicyclo[3.3.1]nonan-9-yl)picolinamide (S)-2-hydroxysuccinate | US10604489, Compound 119 | US11180455, Compound 119
Type:
Small organic molecule
Emp. Form.:
C24H28N4O2
Mol. Mass.:
404.5047
SMILES:
COC1(C2CCCC1CN(Cc1cc3ccccc3[nH]1)C2)c1ccnc(c1)C(N)=O |TLB:21:2:5.4.6:8.20.9,10:9:2:5.4.6,THB:1:2:5.4.6:8.20.9|
Structure:
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