Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM438970
Substrate
n/a
Meas. Tech.
Competitive Displacement Assay
Ki
3±n/a nM
Citation
 Wynn, TA; Alvarez, JC; Moustakas, DT; Haeberlein, M; Pennington, LD Compounds for the treatment of pain US Patent  US10604489 Publication Date 3/31/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM438970
Synonyms:
US10604489, Compound 131
Type:
Small organic molecule
Emp. Form.:
C20H29N3O2
Mol. Mass.:
343.4632
SMILES:
COC1(C2CCCC1CN(C2)C1C[C@H](C)C1)c1ccnc(c1)C(N)=O |r,wU:13.15,TLB:11:9:2:5.4.6,16:2:5.4.6:8.10.9,THB:1:2:5.4.6:8.10.9,(2.15,-2.77,;.81,-2,;.81,-.46,;.02,.85,;.01,2.38,;-1.47,2.77,;-.67,1.46,;-.67,-.07,;-2.16,-.46,;-2.93,.87,;-1.45,.48,;-4.26,.1,;-5.75,.5,;-6.15,-.99,;-7.48,-1.76,;-4.66,-1.38,;2.15,.31,;2.15,1.85,;3.48,2.62,;4.81,1.85,;4.81,.31,;3.48,-.46,;6.15,-.46,;7.48,.31,;6.15,-2,)|
Structure:
Search PDB for entries with ligand similarity: