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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM439025
Substrate
n/a
Meas. Tech.
FL-LSD1 LC-MS Assay
IC50
30.0±n/a nM
Citation
 Du-Cuny, L; Xiao, Q; Xun, G; Zheng, Q Substituted 5-cyanoindole compounds and uses thereof US Patent  US10604502 Publication Date 3/31/2020 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM439025
Synonyms:
US10604502, Ex # 13
Type:
Small organic molecule
Emp. Form.:
C19H17ClN4O
Mol. Mass.:
352.817
SMILES:
Cc1cc2n(cc(-c3cncc(N)c3Cl)c2cc1C#N)[C@H]1C[C@H](O)C1 |r,wU:20.22,wD:22.25,(-4.05,-1.24,;-2.71,-.47,;-1.38,-1.24,;-.05,-.47,;1.42,-.94,;2.32,.3,;1.42,1.55,;1.89,3.01,;.86,4.16,;1.34,5.62,;2.85,5.94,;3.88,4.8,;5.38,5.12,;3.4,3.33,;4.43,2.19,;-.05,1.07,;-1.38,1.84,;-2.71,1.07,;-4.05,1.84,;-5.38,2.61,;1.89,-2.41,;3.27,-3.11,;2.57,-4.48,;3.04,-5.94,;1.19,-3.78,)|
Structure:
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